Profhilo
Improve your Skin’s Hydration & Firmness with Profhilo, at The Calla Clinic in Derbyshire
You may have heard about hyaluronic acid- but why is this so important and relevant? As we age, our skin’s natural production of hyaluronic acid declines, leading to loss of elasticity, dryness, and fine lines and wrinkles.
From the age of 25 our hyaluronic acid levels begin to decline. Clinical studies have shown that by the age of 50 our hyaluronic acid levels decline by 50% and by the age of 75 we have just 25% left!
At a glance
15 – 30 minutes
6 months
Two treatments 4 weeks apart
24 hours
Mild


The Importance of Hyaluronic Acid for Your Skin
Hyaluronic acid is vital for skin health because its role is to attract and retain moisture, keeping the skin hydrated, plump, and smooth. It also supports the collagen & elastin in your skin, helping to nourish and protect from damage.
Loss of hyaluronic acid leads to dryness, a decline in skin elasticity and the formation of fine lines & wrinkles.
How can you improve your HA levels within the deep layers?- Profhilo!
Profhilo is an injectable hyaluronic acid designed to deeply hydrate your skin whilst gently supporting collagen & elastin production. This helps with skin firmness, elasticity, and the prevention of skin ageing.
Profhilo won “Best Injectable” at the 2022 Aesthetics Awards and it’s easy to see why. The first of its kind, Profhilo doesn’t just deliver moisturising hyaluronic acid well beneath the skin. Profhilo uses a patented “nano hybrid complex” (or NAHYCO(R)) gel, which uses hyaluronic acids of different molecular weights to slow down the release and effective “half life” of the serum- this ensures the hyaluronic acid stays within the skin for longer to deliver optimal benefits.
Profhilo is therefore a unique hyaluronic acid injectable, because it has a demonstrably longer effect on the dermal cells it acts upon. This unique formula works to hydrate, plump, and revitalise your skin from within.
FAQs
Why Profhilo is the ideal choice for subtle skin rejuvenation & prevention of premature ageing
Profhilo offers all the benefits you’d expect from a rapid and long-lasting shot of HA for you and your skin:
- Deep hydration: Profhilo delivers intense hydration to the deeper layers of the skin, restoring suppleness and reducing the appearance of fine lines and wrinkles.
- Collagen and elastin boost: The unique hyaluronic acid formula stimulates the production of collagen and elastin, the key proteins responsible for skin firmness and elasticity.
- Natural results: Profhilo enhances your natural features without creating an artificial or “fake” look.
How many treatments do I need?
Profhilo treatment is recommended as a regular treatment as part of a skin maintenance plan to achieve optimal results for on-going skin repair and prevention of ageing. The initial treatment regime is two sessions at 4 weeks apart. Following this, as part of your skin maintenance plan we recommend either of the following options:
One treatment every 3 months or two treatments (at 4 weeks apart) every 6 months.
Is Profhilo safe?
Yes, Profhilo treatment is generally considered safe when administered by a trained, qualified practitioner. Profhilo contains pure, stabilized hyaluronic acid, a substance naturally found in the body, which reduces the risk of adverse reactions or allergies. It’s also free from synthetic chemicals like BDDE (used in some fillers to stabilize HA), making it biocompatible and well-tolerated by most skin types.
As with any injectable treatment, there may be temporary side effects, such as mild swelling, redness, or small bumps at the injection sites, which typically subside within a day or two. Serious side effects are rare, especially when administered by an experienced professional.
There has been a rise in counterfeit Profhilo being used by unregulated professionals, so always check when you are having a treatment that you are receiving the genuine Profhilo product by a qualified medical professional.
How is Profhilo different from dermal filler?
Both Profhilo and dermal filler are made from Hyaluronic Acid- so when it comes to the differences it can become confusing BUT they are very different treatments.
Profhilo is a pure hyaluronic acid gel, containing a mixture of low & high molecular weights in a perfect concentration and ratio to support your skin collagen and help hydration. Profhilo is purely designed to help rejuvenate & nourish your skin and the hyaluronic acid properties are different to the hyaluronic acid used in dermal filler.
Dermal filler treatment does not help to rejuvenate your skin but will help with instant improvement in volume loss, add definition and balance your profile. The hyaluronic acid in dermal filler is a different form, it is thicker in consistency and contains other ingredients to help support its structure and ensure it provides the longevity needed for lasting results.
How is Profhilo different from Polynucleotides?
Profhilo and polynucleotide treatments are both injectables for skin rejuvenation but work differently. As stated above, Profhilo is an injectable hyaluronic acid that enhances hydration and elasticity, while polynucleotides focus on skin repair and regeneration. Polynucleotides are made of DNA fragments that promote tissue repair, cellular regeneration, and reduce inflammation, making them excellent for repairing ageing or damaged skin at a deeper level.
To achieve the best results for skin rejuvenation we recommend combining both treatments. Check out our polynucleotides treatment page to find out more.
Do I need Profhilo if I apply a hyaluronic acid in a facial serum?
In short – YES! Profhilo is more effective than a hyaluronic acid serum because it is injected directly into the skin’s deeper layers, allowing the hyaluronic acid to spread evenly and work from within. This deep delivery stimulates collagen and elastin production, boosts hydration, and improves skin elasticity over time.
In contrast, topical serums only reach the skin’s surface, providing temporary hydration without impacting deeper layers or supporting collagen. Profhilo’s unique formulation and delivery method achieve longer-lasting, visible skin improvements that serums cannot replicate.
Can Profhilo improve the HA levels within the deep layers of skin?
Profhilo is an injectable hyaluronic acid designed to deeply hydrate your skin whilst gently supporting collagen & elastin production. This helps with skin firmness, elasticity and prevention of skin ageing.
Profhilo won “Best Injectable” at the 2022 Aesthetics Awards and it’s easy to see why. The first of its kind, Profhilo doesn’t just deliver moisturising hyaluronic acid well beneath the skin. Profhilo uses a patented “nano hybrid complex” (or NAHYCO(R)) gel, which uses hyaluronic acids of different molecular weights to slow down the release and effective “half life” of the serum- this ensures the hyaluronic acid stays within the skin for longer to deliver optimal benefits.
Profhilo is therefore a unique hyaluronic acid injectable, because it has a demonstrably longer effect on the dermal cells it acts upon. This unique formula works to hydrate, plump, and revitalise your skin from within.
Let’s chat
Posted on jack anthony2024-10-19 Thank you very much to Nurse Cheryl and Teresa for An incredible service. I went in for a facial, which was quite honestly one of the best I have ever had. Thank you very much for looking after me and for your incredible hospitality. I will definitely be coming back for more treatments. Highly recommend!Posted on Hayley Allen2024-10-11 I have been going to the calla clinic for a year now… I feel completely safe with Harriet and Cheryl. They are both medical professionals which for me was an essential requirement. They are both passionate and knowledgeable about their business and were able to reassure an initially nervous me, explain treatments so that I could make an informed decision. I love the results from my treatments and now feel happier with my face and more confident. From the moment you walk through the door Ellie makes you feel at home and welcomed - a really lovely space that I enjoy visiting.Posted on Sangita Dosanjh2024-06-27 A pleasurable visit began on entering the building , to be met by a friendlly receptionist . A professional in depth explanation of skin products to optimise long term care skin care. Wide availability of skin enhancing procedures delivered by Dr.Harriet in a relaxed , and unpressurised environment .Posted on Hardeep Kooner2024-06-18 Lovely Clinic and lovely staff always feel welcomed. Dr Harriet is very thorough with the skincare advice and the treatment. Highly recommended.Posted on anne2024-05-29 The staff are knowledgeable and friendly I was put ease and my procedure was thoroughly explained. I have wasted a lot of money on skin care products over the years that didn’t work. I wish I had known how easy it was to attend a skin clinic for help and advice. My skin improved in weeks. I can thoroughly recommend the calla clinic and their lovely staff.Posted on Julie Purnell2024-02-29 Really glad that I tried the Calla Clinic, I was put at ease straight away and was recommended the right treatment to achieve the result I wanted. The treatment was explained clearly by Dr.Harriet and adjustments made to what was more suitable for me. A lovely friendly team and great experience, would highly recommendPosted on Lyndsey McCabe2023-12-05 5* professional service. Very welcoming. Will never go anywhere else again!!! Thank youPosted on Sally2023-12-02 Have been having various treatments by Cheryl for over 15 years and she is the best and believe me I’m a challenge! She is a perfectionist and can’t recommend her highly enough, I’ve had some terrible experiences beforehand and she has worked marvels. Cheryl never stops learning of the the latest advanced treatments at the forefront of her field and you can be rest assured you get the best and why people but there faith in charlatans out there offering cheap treatments with minimal training is baffling to me so I say to you anyone out there if you want the best then ‘The Calla Clinic’ is it and if I could rate it more stars I would.